Cargando…

Insulin Receptor Isoforms Differently Regulate Cell Proliferation and Apoptosis in the Ligand-Occupied and Unoccupied State

The insulin receptor (IR) presents two isoforms (IR-A and IR-B) that differ for the α-subunit C-terminal. Both isoforms are expressed in all human cells albeit in different proportions, yet their functional properties-when bound or unbound to insulin-are not well characterized. From a cell model dep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Massimino, Michele, Sciacca, Laura, Parrinello, Nunziatina Laura, Scalisi, Nunzio Massimo, Belfiore, Antonino, Vigneri, Riccardo, Vigneri, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395753/ https://www.ncbi.nlm.nih.gov/pubmed/34445431 http://dx.doi.org/10.3390/ijms22168729

Ejemplares similares

Insulin Receptor Isoforms in Cancer
por: Vella, Veronica, et al.
Publicado: (2018)

Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells
por: Stella, Stefania, et al.
Publicado: (2023)

Insulin degludec in the first trimester of pregnancy: Report of two cases
por: Milluzzo, Agostino, et al.
Publicado: (2017)

Maternal Diabetes Impairs Insulin and IGF-1 Receptor Expression and Signaling in Human Placenta
por: Tumminia, Andrea, et al.
Publicado: (2021)

Insulin Analogs and Cancer
por: Sciacca, Laura, et al.
Publicado: (2012)

Increased Thyroid Cancer Incidence in Volcanic Areas: A Role of Increased Heavy Metals in the Environment?
por: Malandrino, Pasqualino, et al.
Publicado: (2020)

Combined Inhibition of Bcl2 and Bcr-Abl1 Exercises Anti-Leukemia Activity but Does Not Eradicate the Primitive Leukemic Cells
por: Massimino, Michele, et al.
Publicado: (2021)

Discoidin domain receptor 1 modulates insulin receptor signaling and biological responses in breast cancer cells
por: Vella, Veronica, et al.
Publicado: (2017)

Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells
por: Vella, Veronica, et al.
Publicado: (2021)

Unoccupied Buildings and Vacant Beds
Publicado: (1911)

Unoccupied Beds in Cottage Hospitals
por: Flemming, Chas. E. S.
Publicado: (1923)

Integrated insulin pump therapy with continuous glucose monitoring for improved adherence: technology update
por: Tumminia, Andrea, et al.
Publicado: (2015)

High BCR::ABL1 Expression Defines CD34+ Cells with Significant Alterations in Signal Transduction, Short-Proliferative Potential and Self-Renewal Ability
por: Massimino, Michele, et al.
Publicado: (2023)

Selective Insulin Receptor Modulators (SIRM): A New Class of Antidiabetes Drugs?
por: Vigneri, Riccardo, et al.
Publicado: (2012)

IRF5 promotes the proliferation of human thyroid cancer cells
por: Massimino, Michele, et al.
Publicado: (2012)

Corticosteroid Pulse Therapy for Graves' Ophthalmopathy Reduces the Relapse Rate of Graves' Hyperthyroidism
por: Le Moli, Rosario, et al.
Publicado: (2020)

The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy
por: Vigneri, Paolo Giovanni, et al.
Publicado: (2015)

A Theoretical Study of the Occupied and Unoccupied Electronic Structure of High- and Intermediate-Spin Transition Metal Phthalocyaninato (Pc) Complexes: VPc, CrPc, MnPc, and FePc
por: Carlotto, Silvia, et al.
Publicado: (2020)

Unoccupied electronic states: fundamentals for XANES, EELS, IPS and BIS
por: Fuggle, John, et al.
Publicado: (1992)

Nanoscale measurements of unoccupied band dispersion in few-layer graphene
por: Jobst, Johannes, et al.
Publicado: (2015)

Chk1 Inhibition Restores Inotuzumab Ozogamicin Citotoxicity in CD22-Positive Cells Expressing Mutant p53
por: Tirrò, Elena, et al.
Publicado: (2019)

Mesenchymal Stem Cells (MSC) Regulate Activation of Granulocyte-Like Myeloid Derived Suppressor Cells (G-MDSC) in Chronic Myeloid Leukemia Patients
por: Giallongo, Cesarina, et al.
Publicado: (2016)

Myeloid Derived Suppressor Cells (MDSCs) Are Increased and Exert Immunosuppressive Activity Together with Polymorphonuclear Leukocytes (PMNs) in Chronic Myeloid Leukemia Patients
por: Giallongo, Cesarina, et al.
Publicado: (2014)

Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation
por: Vella, Veronica, et al.
Publicado: (2019)

Potential Therapeutic Targets for Luminal Androgen Receptor Breast Cancer: What We Know so Far
por: Stella, Stefania, et al.
Publicado: (2023)

Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma
por: Longhitano, Lucia, et al.
Publicado: (2017)

Ligand-Mediated Endocytosis and Trafficking of the Insulin-Like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function
por: Morcavallo, Alaide, et al.
Publicado: (2014)

Heavy Metals in the Environment and Thyroid Cancer
por: Gianì, Fiorenza, et al.
Publicado: (2021)

Detecting Plant Stress Using Thermal and Optical Imagery From an Unoccupied Aerial Vehicle
por: Stutsel, Bonny, et al.
Publicado: (2021)

Temporal phenomic predictions from unoccupied aerial systems can outperform genomic predictions
por: Adak, Alper, et al.
Publicado: (2022)

Single-Cell Analysis in the Omics Era: Technologies and Applications in Cancer
por: Massimino, Michele, et al.
Publicado: (2023)

Prognostic and Therapeutic Roles of the Insulin Growth Factor System in Glioblastoma
por: Tirrò, Elena, et al.
Publicado: (2021)

One Year of Dapaglifozin Add-On Therapy Ameliorates Surrogate Indexes of Insulin Resistance and Adiposity in Patients with Type 2 Diabetes Mellitus
por: Radellini, Stefano, et al.
Publicado: (2021)

Dataset of theoretical Molecular Electrostatic Potential (MEP), Highest Occupied Molecular Orbital-Lowest Unoccupied Molecular Orbital (HOMO-LUMO) band gap and experimental cole-cole plot of 4-(ortho-, meta- and para-fluorophenyl)thiosemicarbazide isomers
por: Silvarajoo, Sharmili, et al.
Publicado: (2020)

Correction to: One Year of Dapaglifozin Add-On Therapy Ameliorates Surrogate Indexes of Insulin Resistance and Adiposity in Patients with Type 2 Diabetes Mellitus
por: Radellini, Stefano, et al.
Publicado: (2021)

Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity
por: Vinciguerra, Federica, et al.
Publicado: (2020)

Reflection of Molecular Twist in Unoccupied Molecular Orbitals in PTCDI Derivatives: A Density Functional Study
por: Mukherjee, Binayak, et al.
Publicado: (2017)

Unoccupied aerial system enabled functional modeling of maize height reveals dynamic expression of loci
por: Anderson, Steven L., et al.
Publicado: (2020)

Novel cross-talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses
por: Malaguarnera, Roberta, et al.
Publicado: (2015)

Liraglutide Improves Cardiovascular Risk as an Add-on to Metformin and Not to Insulin Secretagogues in Type 2 Diabetic Patients: A Real-life 48-Month Retrospective Study
por: Ciresi, Alessandro, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bdtutfdetpaon0t4suos4ohpga