Gain-of-Function Mutant TP53 R248Q Overexpressed in Epithelial Ovarian Carcinoma Alters AKT-Dependent Regulation of Intercellular Trafficking in Responses to EGFR/MDM2 Inhibitor

As the most common gene mutation found in cancers, p53 mutations are detected in up to 96% of high-grade serous ovarian carcinoma (HGSOC). Meanwhile, mutant p53 overexpression is known to drive oncogenic phenotypes in cancer patients and to sustain the activation of EGFR signaling. Previously, we ha...

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Detalles Bibliográficos
Autores principales: Lai, Zih-Yin, Tsai, Kai-Yun, Chang, Shing-Jyh, Chuang, Yung-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395913/
https://www.ncbi.nlm.nih.gov/pubmed/34445495
http://dx.doi.org/10.3390/ijms22168784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395913/
https://www.ncbi.nlm.nih.gov/pubmed/34445495
http://dx.doi.org/10.3390/ijms22168784

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