Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases

Apurinic/apyrimidinic (AP) endonucleases Nfo (Escherichia coli) and APE1 (human) represent two conserved structural families of enzymes that cleave AP-site–containing DNA in base excision repair. Nfo and APE1 have completely different structures of the DNA-binding site, catalytically active amino ac...

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Detalles Bibliográficos
Autores principales: Kuznetsova, Alexandra A., Senchurova, Svetlana I., Ishchenko, Alexander A., Saparbaev, Murat, Fedorova, Olga S., Kuznetsov, Nikita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396254/
https://www.ncbi.nlm.nih.gov/pubmed/34445579
http://dx.doi.org/10.3390/ijms22168874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396254/
https://www.ncbi.nlm.nih.gov/pubmed/34445579
http://dx.doi.org/10.3390/ijms22168874

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