Suppression of LPS-Induced Inflammation and Cell Migration by Azelastine through Inhibition of JNK/NF-κB Pathway in BV2 Microglial Cells

The c-Jun N-terminal kinases (JNKs) are implicated in many neuropathological conditions, including neurodegenerative diseases. To explore potential JNK3 inhibitors from the U.S. Food and Drug Administration-approved drug library, we performed structure-based virtual screening and identified azelasti...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Phuong Linh, Bui, Bich Phuong, Duong, Men Thi Hoai, Lee, Kyeong, Ahn, Hee-Chul, Cho, Jungsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396433/
https://www.ncbi.nlm.nih.gov/pubmed/34445767
http://dx.doi.org/10.3390/ijms22169061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396433/
https://www.ncbi.nlm.nih.gov/pubmed/34445767
http://dx.doi.org/10.3390/ijms22169061

Ejemplares similares