Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is the most common degenerative motor neuron disease in adults. About 97% of ALS patients present TDP-43 aggregates with post-translational modifications, such as hyperphosphorylation, in the cytoplasm of affected cells. GSK-3β is one of the protein kinases involv...

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Detalles Bibliográficos
Autores principales: Martínez-González, Loreto, Gonzalo-Consuegra, Claudia, Gómez-Almería, Marta, Porras, Gracia, de Lago, Eva, Martín-Requero, Ángeles, Martínez, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396476/
https://www.ncbi.nlm.nih.gov/pubmed/34445680
http://dx.doi.org/10.3390/ijms22168975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396476/
https://www.ncbi.nlm.nih.gov/pubmed/34445680
http://dx.doi.org/10.3390/ijms22168975

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