Cargando…

Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is the most common degenerative motor neuron disease in adults. About 97% of ALS patients present TDP-43 aggregates with post-translational modifications, such as hyperphosphorylation, in the cytoplasm of affected cells. GSK-3β is one of the protein kinases involv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martínez-González, Loreto, Gonzalo-Consuegra, Claudia, Gómez-Almería, Marta, Porras, Gracia, de Lago, Eva, Martín-Requero, Ángeles, Martínez, Ana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396476/ https://www.ncbi.nlm.nih.gov/pubmed/34445680 http://dx.doi.org/10.3390/ijms22168975

Ejemplares similares

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis
por: Martín-Cámara, Olmo, et al.
Publicado: (2022)

Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations
por: Maestro, Ines, et al.
Publicado: (2022)

GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib
por: Li, Junyu, et al.
Publicado: (2020)

Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson’s Disease and Amyotrophic Lateral Sclerosis
por: Burgaz, Sonia, et al.
Publicado: (2021)

Tideglusib, a prospective alternative to nonoxynol-9 contraceptive
por: Chen, Zhiting, et al.
Publicado: (2019)

BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis
por: Gómez-Almería, Marta, et al.
Publicado: (2021)

Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral Sclerosis
por: Choi, Hyun-Jun, et al.
Publicado: (2020)

Liquid biopsy: a new source of candidate biomarkers in amyotrophic lateral sclerosis
por: Mendioroz, Maite, et al.
Publicado: (2018)

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
por: Lastres-Becker, Isabel, et al.
Publicado: (2022)

Inactivation of the CB(2) receptor accelerated the neuropathological deterioration in TDP‐43 transgenic mice, a model of amyotrophic lateral sclerosis
por: Rodríguez‐Cueto, Carmen, et al.
Publicado: (2021)

Cystatin C: A Candidate Biomarker for Amyotrophic Lateral Sclerosis
por: Wilson, Meghan E., et al.
Publicado: (2010)

Urinary biomarkers for amyotrophic lateral sclerosis: candidates, opportunities and considerations
por: Rogers, Mary-Louise, et al.
Publicado: (2023)

Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma
por: Bharathy, Narendra, et al.
Publicado: (2017)

A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β
por: Swinney, Zachary T., et al.
Publicado: (2016)

Functional Characterization of a Familial ALS-Associated Missense TBK1 (p-Arg573Gly) Mutation in Patient-Derived Lymphoblasts
por: Porras, Gracia, et al.
Publicado: (2023)

Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons
por: Pozner, Tatyana, et al.
Publicado: (2018)

Amyotrophic lateral sclerosis
por: Wijesekera, Lokesh C, et al.
Publicado: (2009)

Are Circulating Cytokines Reliable Biomarkers for Amyotrophic Lateral Sclerosis?
por: Moreno-Martinez, Laura, et al.
Publicado: (2019)

Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway
por: Sun, Jiachen, et al.
Publicado: (2022)

Evaluating the Effect of Tideglusib-Loaded Bioactive Glass Nanoparticles as a Potential Dentine Regenerative Material
por: Rao, Akhil C., et al.
Publicado: (2022)

Upregulation of CB(2) receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis
por: Fernández-Trapero, María, et al.
Publicado: (2017)

MicroRNA-206: A Potential Circulating Biomarker Candidate for Amyotrophic Lateral Sclerosis
por: Toivonen, Janne M., et al.
Publicado: (2014)

UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis
por: Li, Ruibing, et al.
Publicado: (2020)

A candidate protective factor in amyotrophic lateral sclerosis: heterogenous nuclear ribonucleoprotein G
por: Yang, Fang, et al.
Publicado: (2022)

Amyotrophic lateral sclerosis and neuroregeneration
Publicado: (2012)

Mimickers of Amyotrophic Lateral Sclerosis
por: Dubey, Ayush, et al.
Publicado: (2019)

Destination Amyotrophic Lateral Sclerosis
por: Keon, Matt, et al.
Publicado: (2021)

Prionoids in amyotrophic lateral sclerosis
por: Gosset, Philippe, et al.
Publicado: (2022)

Amyotrophic lateral sclerosis and cerebellum
por: Kabiljo, Renata, et al.
Publicado: (2022)

Dysautonomia in Amyotrophic Lateral Sclerosis
por: Oprisan, Alexandra L., et al.
Publicado: (2023)

Tideglusib Inhibits Pif1 Helicase of Bacteroides sp. via an Irreversible and Cys-380-Dependent Mechanism
por: Zhou, Xianglian, et al.
Publicado: (2022)

Human CCS gene: genomic organization and exclusion as a candidate for amyotrophic lateral sclerosis (ALS)
por: Silahtaroglu, Asli N, et al.
Publicado: (2002)

The Extracellular Domain of Neurotrophin Receptor p75 as a Candidate Biomarker for Amyotrophic Lateral Sclerosis
por: Shepheard, Stephanie R., et al.
Publicado: (2014)

Telematic adaptation to home mechanical ventilation in patients with amyotrophic lateral sclerosis
por: Balañá, A., et al.
Publicado: (2023)

Clinical Psychology and Amyotrophic Lateral Sclerosis
por: Pagnini, Francesco, et al.
Publicado: (2010)

Glial Cells in Amyotrophic Lateral Sclerosis
por: Lasiene, Jurate, et al.
Publicado: (2011)

The Cortical Signature of Amyotrophic Lateral Sclerosis
por: Agosta, Federica, et al.
Publicado: (2012)

Redox Regulation in Amyotrophic Lateral Sclerosis
por: Parakh, Sonam, et al.
Publicado: (2013)

Genetics of amyotrophic lateral sclerosis: an update
por: Chen, Sheng, et al.
Publicado: (2013)

Protein aggregation in amyotrophic lateral sclerosis
por: Blokhuis, Anna M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_lkdhmo9ahbplrfmkslet0v4v2o