Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of K(V)10.1 Pore Blockers

The K(V)10.1 voltage-gated potassium channel is highly expressed in 70% of tumors, and thus represents a promising target for anticancer drug discovery. However, only a few ligands are known to inhibit K(V)10.1, and almost all also inhibit the very similar cardiac hERG channel, which can lead to und...

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Detalles Bibliográficos
Autores principales: Toplak, Žan, Merzel, Franci, Pardo, Luis A., Peterlin Mašič, Lucija, Tomašič, Tihomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396485/
https://www.ncbi.nlm.nih.gov/pubmed/34445705
http://dx.doi.org/10.3390/ijms22168999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396485/
https://www.ncbi.nlm.nih.gov/pubmed/34445705
http://dx.doi.org/10.3390/ijms22168999

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