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Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of K(V)10.1 Pore Blockers
The K(V)10.1 voltage-gated potassium channel is highly expressed in 70% of tumors, and thus represents a promising target for anticancer drug discovery. However, only a few ligands are known to inhibit K(V)10.1, and almost all also inhibit the very similar cardiac hERG channel, which can lead to und...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396485/ https://www.ncbi.nlm.nih.gov/pubmed/34445705 http://dx.doi.org/10.3390/ijms22168999 |