Simultaneous Monitoring of Monoclonal Antibody Variants by Strong Cation-Exchange Chromatography Hyphenated to Mass Spectrometry to Assess Quality Attributes of Rituximab-Based Biotherapeutics

Different manufacturing processes and storage conditions of biotherapeutics can lead to a significant variability in drug products arising from chemical and enzymatic post-translational modifications (PTMs), resulting in the co-existence of a plethora of proteoforms with different physicochemical pr...

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Detalles Bibliográficos
Autores principales: Di Marco, Fiammetta, Berger, Thomas, Esser-Skala, Wolfgang, Rapp, Erdmann, Regl, Christof, Huber, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396523/
https://www.ncbi.nlm.nih.gov/pubmed/34445776
http://dx.doi.org/10.3390/ijms22169072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396523/
https://www.ncbi.nlm.nih.gov/pubmed/34445776
http://dx.doi.org/10.3390/ijms22169072

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