Cargando…

Simultaneous Monitoring of Monoclonal Antibody Variants by Strong Cation-Exchange Chromatography Hyphenated to Mass Spectrometry to Assess Quality Attributes of Rituximab-Based Biotherapeutics

Different manufacturing processes and storage conditions of biotherapeutics can lead to a significant variability in drug products arising from chemical and enzymatic post-translational modifications (PTMs), resulting in the co-existence of a plethora of proteoforms with different physicochemical pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Marco, Fiammetta, Berger, Thomas, Esser-Skala, Wolfgang, Rapp, Erdmann, Regl, Christof, Huber, Christian G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396523/ https://www.ncbi.nlm.nih.gov/pubmed/34445776 http://dx.doi.org/10.3390/ijms22169072

Ejemplares similares

Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies
por: Ma, Fengfei, et al.
Publicado: (2020)

Dilute-and-shoot analysis of therapeutic monoclonal antibody variants in fermentation broth: a method capability study
por: Regl, Christof, et al.
Publicado: (2019)

Identification and Quantification of Oxidation Products in Full-Length Biotherapeutic Antibodies by NMR Spectroscopy
por: Hinterholzer, Arthur, et al.
Publicado: (2020)

Online Collision-Induced Unfolding of Therapeutic Monoclonal Antibody Glyco-Variants through Direct Hyphenation of Cation Exchange Chromatography with Native Ion Mobility–Mass Spectrometry
por: van Schaick, Guusje, et al.
Publicado: (2023)

A Simple Strategy to Eliminate Hexosylation Bias in the Relative Quantification of N‐Glycosylation in Biopharmaceuticals
por: Esser‐Skala, Wolfgang, et al.
Publicado: (2020)

Unambiguous identification of α-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy
por: Hinterholzer, Arthur, et al.
Publicado: (2022)

Hyphenation of Supercritical Fluid Chromatography and NMR with In-Line Sample Concentration
por: van Zelst, F. H. M., et al.
Publicado: (2018)

Rituximab-specific DNA aptamers are able to selectively recognize heat-treated antibodies
por: Kohlberger, Michael, et al.
Publicado: (2020)

Strong Cation Exchange Chromatography in Analysis of Posttranslational Modifications: Innovations and Perspectives
por: Edelmann, Mariola J.
Publicado: (2011)

Probing the Complementarity of FAIMS and Strong Cation Exchange Chromatography in Shotgun Proteomics
por: Creese, Andrew J., et al.
Publicado: (2013)

Aptamers as quality control tool for production, storage and biosimilarity of the anti-CD20 biopharmaceutical rituximab
por: Wildner, Sabrina, et al.
Publicado: (2019)

Size-Exclusion Chromatography for the Analysis of Protein Biotherapeutics and their Aggregates
por: Hong, Paula, et al.
Publicado: (2012)

Biotherapeutics: Challenges and Opportunities for Predictive Toxicology of Monoclonal Antibodies
por: Johnson, Dale E.
Publicado: (2018)

Online hyphenation of centrifugal partition chromatography with countercurrent chromatography (CPC-CCC) and its application to the separation of saturated alkylresorcinols
por: Hammerschick, Tim, et al.
Publicado: (2022)

Analytical Method Development for Determining Formaldehyde in Cream Cosmetics Using Hyphenated Gas Chromatography
por: Yuniati, Wiwiet, et al.
Publicado: (2021)

Analysis of sequence-defined oligomers through Advanced Polymer Chromatography™ – mass spectrometry hyphenation
por: Berg, Marie-Theres, et al.
Publicado: (2020)

High-Temperature Liquid Chromatography and the Hyphenation with Mass Spectrometry Using High-Pressure Electrospray Ionization
por: Chen, Lee Chuin
Publicado: (2019)

Online hyphenation of size‐exclusion chromatography and gas‐phase electrophoresis facilitates the characterization of protein aggregates
por: Weiss, Victor U., et al.
Publicado: (2021)

Chemometric Profile of Root Extracts of Rhodiola imbricata Edgew. with Hyphenated Gas Chromatography Mass Spectrometric Technique
por: Tayade, Amol B., et al.
Publicado: (2013)

High-Performance Thin-Layer Chromatography Hyphenated with Microchemical and Biochemical Derivatizations in Bioactivity Profiling of Marine Species
por: Agatonovic-Kustrin, Snezana, et al.
Publicado: (2019)

Alkaloids Profiling of Fumaria capreolata by Analytical Platforms Based on the Hyphenation of Gas Chromatography and Liquid Chromatography with Quadrupole-Time-of-Flight Mass Spectrometry
por: Contreras, María del Mar, et al.
Publicado: (2017)

An evaluation of instrument types for mass spectrometry-based multi-attribute analysis of biotherapeutics
por: Zhang, Zhongqi, et al.
Publicado: (2020)

Introduction to hyphenated techniques and their applications in pharmacy
por: Patel, Kalpesh N, et al.
Publicado: (2010)

Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies
por: Rane, Shraddha S., et al.
Publicado: (2019)

Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry
por: Haberger, Markus, et al.
Publicado: (2015)

Rapid Analysis of Biotherapeutics Using Protein A Chromatography Coupled to Orbitrap Mass Spectrometry
por: Jakes, Craig, et al.
Publicado: (2021)

Determination of Oleanolic and Ursolic Acids in Hedyotis diffusa Using Hyphenated Ultrasound-Assisted Supercritical Carbon Dioxide Extraction and Chromatography
por: Wei, Ming-Chi, et al.
Publicado: (2015)

A Novel Targeted Analysis of Peripheral Steroids by Ultra-Performance Supercritical Fluid Chromatography Hyphenated to Tandem Mass Spectrometry
por: de Kock, Neil, et al.
Publicado: (2018)

Puree and Juice of Thai Mango and Pineapple Analyzed by High-Performance Thin-Layer Chromatography Hyphenated with Effect-Directed Assays
por: Morlock, Gertrud E., et al.
Publicado: (2021)

A Universal Eluent System for Method Scouting and Separation of Biotherapeutic Proteins by Ion-Exchange, Size-Exclusion, and Hydrophobic Interaction Chromatography
por: Schwahn, Alexander B., et al.
Publicado: (2022)

Biophysics - whence, whither, wherefore - or Hold that hyphen
por: Gratzer, Walter B
Publicado: (2011)

Editorial to Multidimensional and Hyphenated Techniques in Separation Science
por: De Vos, Jelle, et al.
Publicado: (2021)

Hyphenated structural identification of additives in transmission fluids
por: van Zelst, F. H. M., et al.
Publicado: (2022)

Exploring the Chemical Space of Protein Glycosylation in Noncovalent Protein Complexes: An Expedition along Different Structural Levels of Human Chorionic Gonadotropin by Employing Mass Spectrometry
por: Lebede, Maximilian, et al.
Publicado: (2021)

Advances in the Development of Biotherapeutics
por: Oliveira, Pedro H., et al.
Publicado: (2015)

Integrated BioTherapeutics
por: Aman, M. Javad
Publicado: (2018)

Electroextraction and electromembrane extraction: Advances in hyphenation to analytical techniques
por: Oedit, Amar, et al.
Publicado: (2016)

Hyphenating size‐exclusion chromatography with electrospray mass spectrometry; using on‐line liquid‐liquid extraction to study the lipid composition of lipoprotein particles
por: Osei, Michael, et al.
Publicado: (2015)

Elucidation of Flavonoids from Carissa congesta, Polyalthia longifolia, and Benincasa hispida Plant Extracts by Hyphenated Technique of Liquid Chromatography-mass Spectroscopy
por: Doshi, Gaurav M., et al.
Publicado: (2016)

Bioactivity Profiling and Quantification of Gastrodin in Gastrodia elata Cultivated in the Field versus Facility via Hyphenated High-Performance Thin-Layer Chromatography
por: Mügge, Fernanda L. B., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t08a06qboam2om4vt9eq0op282