Airway Exposure to Polyethyleneimine Nanoparticles Induces Type 2 Immunity by a Mechanism Involving Oxidative Stress and ATP Release

Polyethyleneimine (PEI) induced immune responses were investigated in human bronchial epithelial (hBE) cells and mice. PEI rapidly induced ATP release from hBE cells and pretreatment with glutathione (GSH) blocked the response. PEI activated two conductive pathways, VDAC-1 and pannexin 1, which comp...

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Detalles Bibliográficos
Autores principales: Srisomboon, Yotesawee, Ohkura, Noriyuki, Iijima, Koji, Kobayashi, Takao, Maniak, Peter J., Kita, Hirohito, O’Grady, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396525/
https://www.ncbi.nlm.nih.gov/pubmed/34445774
http://dx.doi.org/10.3390/ijms22169071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396525/
https://www.ncbi.nlm.nih.gov/pubmed/34445774
http://dx.doi.org/10.3390/ijms22169071

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