Decreased Interactions between Calmodulin and a Mutant Huntingtin Model Might Reduce the Cytotoxic Level of Intracellular Ca(2+): A Molecular Dynamics Study

Mutant huntingtin (m-HTT) proteins and calmodulin (CaM) co-localize in the cerebral cortex with significant effects on the intracellular calcium levels by altering the specific calcium-mediated signals. Furthermore, the mutant huntingtin proteins show great affinity for CaM that can lead to a furthe...

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Detalles Bibliográficos
Autores principales: Moldovean, Sanda Nastasia, Chiş, Vasile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396531/
https://www.ncbi.nlm.nih.gov/pubmed/34445734
http://dx.doi.org/10.3390/ijms22169025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396531/
https://www.ncbi.nlm.nih.gov/pubmed/34445734
http://dx.doi.org/10.3390/ijms22169025

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