Complex Conformational Dynamics of the Heart Failure-Associated Pre-miRNA-377 Hairpin Revealed by Single-Molecule Optical Tweezers

Pre-miRNA-377 is a hairpin-shaped regulatory RNA associated with heart failure. Here, we use single-molecule optical tweezers to unzip pre-miRNA-377 and study its stability and dynamics. We show that magnesium ions have a strong stabilizing effect, and that sodium ions stabilize the hairpin more tha...

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Detalles Bibliográficos
Autores principales: Wypijewska del Nogal, Anna, Sundar Rajan, Vinoth, Westerlund, Fredrik, Wilhelmsson, L. Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396532/
https://www.ncbi.nlm.nih.gov/pubmed/34445712
http://dx.doi.org/10.3390/ijms22169008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396532/
https://www.ncbi.nlm.nih.gov/pubmed/34445712
http://dx.doi.org/10.3390/ijms22169008

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