Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival mechanisms governed by the tumor hypoxia–induced pH regulator carbonic anhydrase IX (CAIX). We identified a redox homeostasis...

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Detalles Bibliográficos
Autores principales: Chafe, Shawn C., Vizeacoumar, Frederick S., Venkateswaran, Geetha, Nemirovsky, Oksana, Awrey, Shannon, Brown, Wells S., McDonald, Paul C., Carta, Fabrizio, Metcalfe, Andrew, Karasinska, Joanna M., Huang, Ling, Muthuswamy, Senthil K., Schaeffer, David F., Renouf, Daniel J., Supuran, Claudiu T., Vizeacoumar, Franco J., Dedhar, Shoukat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397268/
https://www.ncbi.nlm.nih.gov/pubmed/34452919
http://dx.doi.org/10.1126/sciadv.abj0364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397268/
https://www.ncbi.nlm.nih.gov/pubmed/34452919
http://dx.doi.org/10.1126/sciadv.abj0364

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