Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage

Double-strand breaks (DSBs) are harmful lesions and a major cause of genome instability. Studies have suggested a link between the nuclear envelope and the DNA damage response. Here, we show that lamin B1, a major component of the nuclear envelope, interacts directly with 53BP1 protein, which plays...

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Detalles Bibliográficos
Autores principales: Etourneaud, Laure, Moussa, Angela, Rass, Emilie, Genet, Diane, Willaume, Simon, Chabance-Okumura, Caroline, Wanschoor, Paul, Picotto, Julien, Thézé, Benoît, Dépagne, Jordane, Veaute, Xavier, Dizet, Eléa, Busso, Didier, Barascu, Aurélia, Irbah, Lamya, Kortulewski, Thierry, Campalans, Anna, Le Chalony, Catherine, Zinn-Justin, Sophie, Scully, Ralph, Pennarun, Gaëlle, Bertrand, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397269/
https://www.ncbi.nlm.nih.gov/pubmed/34452908
http://dx.doi.org/10.1126/sciadv.abb3799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397269/
https://www.ncbi.nlm.nih.gov/pubmed/34452908
http://dx.doi.org/10.1126/sciadv.abb3799

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