A General Iridium-Catalyzed Reductive Dienamine Synthesis Allows a Five-Step Synthesis of Catharanthine via the Elusive Dehydrosecodine

[Image: see text] A new reductive strategy for the stereo- and regioselective synthesis of functionalized isoquinuclidines has been developed. Pivoting on the chemoselective iridium(I)-catalyzed reductive activation of β,γ-unsaturated δ-lactams, the efficiently produced reactive dienamine intermedia...

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Detalles Bibliográficos
Autores principales: Gabriel, Pablo, Almehmadi, Yaseen A., Wong, Zeng Rong, Dixon, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397322/
https://www.ncbi.nlm.nih.gov/pubmed/34254792
http://dx.doi.org/10.1021/jacs.1c04980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397322/
https://www.ncbi.nlm.nih.gov/pubmed/34254792
http://dx.doi.org/10.1021/jacs.1c04980

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