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A General Iridium-Catalyzed Reductive Dienamine Synthesis Allows a Five-Step Synthesis of Catharanthine via the Elusive Dehydrosecodine
[Image: see text] A new reductive strategy for the stereo- and regioselective synthesis of functionalized isoquinuclidines has been developed. Pivoting on the chemoselective iridium(I)-catalyzed reductive activation of β,γ-unsaturated δ-lactams, the efficiently produced reactive dienamine intermedia...
Autores principales: | Gabriel, Pablo, Almehmadi, Yaseen A., Wong, Zeng Rong, Dixon, Darren J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397322/ https://www.ncbi.nlm.nih.gov/pubmed/34254792 http://dx.doi.org/10.1021/jacs.1c04980 |
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