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Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

Clustering of ligand:receptor complexes on the cell membrane is widely presumed to have functional consequences for subsequent signal transduction. However, it is experimentally challenging to selectively manipulate receptor clustering without altering other biochemical aspects of the cellular syste...

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Detalles Bibliográficos
Autores principales: Chen, Zhongwen, Oh, Dongmyung, Biswas, Kabir Hassan, Zaidel-Bar, Ronen, Groves, Jay T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397371/
https://www.ncbi.nlm.nih.gov/pubmed/34414885
http://dx.doi.org/10.7554/eLife.67379