Halogenation at the Phenylalanine Residue of Monomethyl Auristatin F Leads to a Favorable cis/trans Equilibrium and Retained Cytotoxicity

[Image: see text] Halogenation can be utilized for the purposes of labeling and molecular imaging, providing a means to, e.g., follow drug distribution in an organism through positron emission tomography (PET) or study the molecular recognition events unfolding by nuclear magnetic resonance (NMR) sp...

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Detalles Bibliográficos
Autores principales: Sokka, Iris K., Imlimthan, Surachet, Sarparanta, Mirkka, Maaheimo, Hannu, Johansson, Mikael P., Ekholm, Filip S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397390/
https://www.ncbi.nlm.nih.gov/pubmed/34296616
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397390/
https://www.ncbi.nlm.nih.gov/pubmed/34296616
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00342

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