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Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART

Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets contributed to divergent CD4 T-cell recovery and HIV reservoir...

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Detalles Bibliográficos
Autores principales: Pino, Maria, Pereira Ribeiro, Susan, Pagliuzza, Amélie, Ghneim, Khader, Khan, Anum, Ryan, Emily, Harper, Justin L., King, Colin T., Welbourn, Sarah, Micci, Luca, Aldrete, Sol, Delman, Keith A., Stuart, Theron, Lowe, Michael, Brenchley, Jason M., Derdeyn, Cynthia A., Easley, Kirk, Sekaly, Rafick P., Chomont, Nicolas, Paiardini, Mirko, Marconi, Vincent C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397407/
https://www.ncbi.nlm.nih.gov/pubmed/34449812
http://dx.doi.org/10.1371/journal.ppat.1009825