Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation

[Image: see text] A major risk factor for Gaucher’s disease is loss of function mutations in the GBA1 gene that encodes lysosomal β-glucocerebrosidase, resulting in accumulation of glucosylceramide (GlcCer), a key lysosomal sphingolipid. GBA1 mutations also enhance the risk for Parkinson’s disease,...

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Detalles Bibliográficos
Autores principales: Paul, Ashim, Jacoby, Guy, Laor Bar-Yosef, Dana, Beck, Roy, Gazit, Ehud, Segal, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397424/
https://www.ncbi.nlm.nih.gov/pubmed/34213307
http://dx.doi.org/10.1021/acsnano.1c02957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397424/
https://www.ncbi.nlm.nih.gov/pubmed/34213307
http://dx.doi.org/10.1021/acsnano.1c02957

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