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Design and synthesis of analogues of RA-VII—an antitumor bicyclic hexapeptide from Rubiae radix

The 14-membered cycloisodityrosine is the core structure of RA-series antitumor bicyclic peptides obtained from Rubia plants (Rubiaceae). In this study, an efficient method for the synthesis of cycloisodityrosines from commercially available l-tyrosine derivatives was developed. Using synthetic cycl...

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Detalles Bibliográficos
Autor principal: Hitotsuyanagi, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397687/
https://www.ncbi.nlm.nih.gov/pubmed/34244894
http://dx.doi.org/10.1007/s11418-021-01542-w