Selective involution of thymic medulla by cyclosporine A with a decrease of mature thymic epithelia, XCR1(+) dendritic cells, and epithelium-free areas containing Foxp3(+) thymic regulatory T cells

Immunosuppressive drugs such as cyclosporine A (CSA) can disrupt thymic structure and functions, ultimately inducing syngeneic/autologous graft-versus-host disease together with involuted medullas. To elucidate the effects of CSA on the thymus more precisely, we analyzed the effects of CSA on the th...

Descripción completa

Detalles Bibliográficos
Autores principales: Sawanobori, Yasushi, Kitazawa, Yusuke, Ueta, Hisashi, Matsuno, Kenjiro, Tokuda, Nobuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397693/
https://www.ncbi.nlm.nih.gov/pubmed/33993340
http://dx.doi.org/10.1007/s00418-021-01993-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397693/
https://www.ncbi.nlm.nih.gov/pubmed/33993340
http://dx.doi.org/10.1007/s00418-021-01993-y

Ejemplares similares