Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade

Monoclonal antibodies that target the inhibitory immune checkpoint axis consisting of programmed cell death protein 1 (PD-1) and its ligand, PD-L1, have changed the immune-oncology field. We identified K2, an anti-human PD-L1 single-domain antibody fragment, that can enhance T cell activation and tu...

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Detalles Bibliográficos
Autores principales: Awad, Robin Maximilian, Lecocq, Quentin, Zeven, Katty, Ertveldt, Thomas, De Beck, Lien, Ceuppens, Hannelore, Broos, Katrijn, De Vlaeminck, Yannick, Goyvaerts, Cleo, Verdonck, Magali, Raes, Geert, Van Parys, Alexander, Cauwels, Anje, Keyaerts, Marleen, Devoogdt, Nick, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397838/
https://www.ncbi.nlm.nih.gov/pubmed/34485603
http://dx.doi.org/10.1016/j.omtm.2021.05.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397838/
https://www.ncbi.nlm.nih.gov/pubmed/34485603
http://dx.doi.org/10.1016/j.omtm.2021.05.017

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