A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide

We previously developed single App knock-in mouse models of Alzheimer's disease (AD) harboring the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation (App(NL-G-F) and App(NL-F) mice, respectively). These models showed Aβ pathology, neuroinflammation, and cognitive impa...

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Detalles Bibliográficos
Autores principales: Sato, Kaori, Watamura, Naoto, Fujioka, Ryo, Mihira, Naomi, Sekiguchi, Misaki, Nagata, Kenichi, Ohshima, Toshio, Saito, Takashi, Saido, Takaomi C., Sasaguri, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397900/
https://www.ncbi.nlm.nih.gov/pubmed/34329683
http://dx.doi.org/10.1016/j.jbc.2021.101004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397900/
https://www.ncbi.nlm.nih.gov/pubmed/34329683
http://dx.doi.org/10.1016/j.jbc.2021.101004

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