Cargando…

A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide

We previously developed single App knock-in mouse models of Alzheimer's disease (AD) harboring the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation (App(NL-G-F) and App(NL-F) mice, respectively). These models showed Aβ pathology, neuroinflammation, and cognitive impa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sato, Kaori, Watamura, Naoto, Fujioka, Ryo, Mihira, Naomi, Sekiguchi, Misaki, Nagata, Kenichi, Ohshima, Toshio, Saito, Takashi, Saido, Takaomi C., Sasaguri, Hiroki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397900/ https://www.ncbi.nlm.nih.gov/pubmed/34329683 http://dx.doi.org/10.1016/j.jbc.2021.101004

Ejemplares similares

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities
por: Watamura, Naoto, et al.
Publicado: (2022)

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
por: Sasaguri, Hiroki, et al.
Publicado: (2018)

Recent Advances in the Modeling of Alzheimer’s Disease
por: Sasaguri, Hiroki, et al.
Publicado: (2022)

Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-K(ATP) channel pathway
por: Watamura, Naoto, et al.
Publicado: (2021)

Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation
por: Hashimoto, Shoko, et al.
Publicado: (2023)

Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden
por: McKee, Celia A., et al.
Publicado: (2022)

Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
por: SAIDO, Takaomi C.
Publicado: (2013)

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis
por: Jiang, Richeng, et al.
Publicado: (2022)

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease
por: Sakakibara, Yasufumi, et al.
Publicado: (2019)

Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged App(NL-G-F/NL-G-F) mice
por: Niikura, Ryo, et al.
Publicado: (2022)

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model
por: Rice, Heather C., et al.
Publicado: (2020)

Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

APP mouse models for Alzheimer's disease preclinical studies
por: Sasaguri, Hiroki, et al.
Publicado: (2017)

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease
por: Kaneko, Ryusei, et al.
Publicado: (2023)

NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load
por: Pohlkamp, Theresa, et al.
Publicado: (2021)

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
por: Nagata, Kenichi, et al.
Publicado: (2018)

Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders
por: Nagata, Kenichi, et al.
Publicado: (2017)

The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
por: Yoshimura, Rikuya, et al.
Publicado: (2023)

Early Identification of Alzheimer's Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters
por: Sutoko, Stephanie, et al.
Publicado: (2021)

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ(42)-Induced Pathways to Alzheimer’s Disease Pathology
por: Schedin-Weiss, Sophia, et al.
Publicado: (2020)

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
por: Hashimoto, Tadafumi, et al.
Publicado: (2020)

Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice
por: Tachida, Yuriko, et al.
Publicado: (2022)

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior
por: Ho, Hinze, et al.
Publicado: (2023)

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
por: Iwata, Nobuhisa, et al.
Publicado: (2013)

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification
por: Kokubo, Hideko, et al.
Publicado: (2009)

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain
por: Ni, Junjun, et al.
Publicado: (2019)

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
por: Clayton, Kevin, et al.
Publicado: (2021)

Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms
por: Schwartz, Kelly, et al.
Publicado: (2012)

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice
por: Kidana, Kiwami, et al.
Publicado: (2018)

Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old App(NL/NL) Knock-In Mice
por: Salas, Isabel H., et al.
Publicado: (2018)

Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
por: Clayton, Kevin, et al.
Publicado: (2021)

Examining the differential effects of information about the death penalty on retributivists and non-retributivists in Japan: a refutation of Marshall's third hypothesis
por: Watamura, Eiichiro, et al.
Publicado: (2023)

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide
por: Nilsson, Per, et al.
Publicado: (2014)

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease
por: Hashimoto, Shoko, et al.
Publicado: (2018)

Neuroinflammation in mouse models of Alzheimer's disease
por: Saito, Takashi, et al.
Publicado: (2018)

A Proteomic Atlas of Cardiac Amyloid Plaques
por: Kourelis, Taxiarchis V., et al.
Publicado: (2020)

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice
por: Wang, Shuo, et al.
Publicado: (2018)

Aggressive Angiomyxoma of the Pelvis with a Cellular Nodule Composed of Tumor Cells showing Epithelioid Features
por: Tajima, Shogo, et al.
Publicado: (2014)

Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice
por: Wang, Shuo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_chp1uej3f2p0hic7vhrt9dpuev