α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues

Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli. Two of them are among the best 1-deoxy-d-xylulose 5-phosphate reductoisomerase inhibitors, with IC(50) in the nM range, much better than f...

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Detalles Bibliográficos
Autores principales: Dreneau, Aurore, Krebs, Fanny S., Munier, Mathilde, Ngov, Chheng, Tritsch, Denis, Lièvremont, Didier, Rohmer, Michel, Grosdemange-Billiard, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397956/
https://www.ncbi.nlm.nih.gov/pubmed/34443699
http://dx.doi.org/10.3390/molecules26165111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397956/
https://www.ncbi.nlm.nih.gov/pubmed/34443699
http://dx.doi.org/10.3390/molecules26165111

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