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α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues

Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli. Two of them are among the best 1-deoxy-d-xylulose 5-phosphate reductoisomerase inhibitors, with IC(50) in the nM range, much better than f...

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Detalles Bibliográficos
Autores principales:	Dreneau, Aurore, Krebs, Fanny S., Munier, Mathilde, Ngov, Chheng, Tritsch, Denis, Lièvremont, Didier, Rohmer, Michel, Grosdemange-Billiard, Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397956/ https://www.ncbi.nlm.nih.gov/pubmed/34443699 http://dx.doi.org/10.3390/molecules26165111

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