Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells

Hydroxycamptothecin (SN38) is a natural plant extract isolated from Camptotheca acuminate. It has a broad spectrum of anticancer activity through inhibition of DNA topoisomerase I, which could affect DNA synthesis and lead to DNA damage. Thus, the action of SN38 against cancers could inevitably affe...

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Detalles Bibliográficos
Autores principales: Li, Yan, Luo, Wendi, Zhang, Huixia, Wang, Caiyun, Yu, Caiyuan, Jiang, Zhihong, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398164/
https://www.ncbi.nlm.nih.gov/pubmed/34443490
http://dx.doi.org/10.3390/molecules26164902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398164/
https://www.ncbi.nlm.nih.gov/pubmed/34443490
http://dx.doi.org/10.3390/molecules26164902

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