Cargando…

Ataluren—Promising Therapeutic Premature Termination Codon Readthrough Frontrunner

Around 12% of hereditary disease-causing mutations are in-frame nonsense mutations. The expression of genes containing nonsense mutations potentially leads to the production of truncated proteins with residual or virtually no function. However, the translation of transcripts containing premature sto...

Descripción completa

Detalles Bibliográficos
Autor principal:	Michorowska, Sylwia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398184/ https://www.ncbi.nlm.nih.gov/pubmed/34451881 http://dx.doi.org/10.3390/ph14080785

Ejemplares similares

Caffeine boosts Ataluren's readthrough activity
por: Lentini, Laura, et al.
Publicado: (2019)

Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development
por: Li, Shan, et al.
Publicado: (2023)

Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons
por: Dabrowski, Maciej, et al.
Publicado: (2018)

Ataluren suppresses a premature termination codon in an MPS I-H mouse
por: Wang, Dan, et al.
Publicado: (2022)

The unfolded protein response affects readthrough of premature termination codons
por: Oren, Yifat S, et al.
Publicado: (2014)

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR
por: Smith, Emery, et al.
Publicado: (2020)

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2016)

Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay
por: Lentini, Laura, et al.
Publicado: (2014)

Letter to the Editor: Liver Cell Models for Premature Termination Codon Readthrough Analyses
por: Matakovic, Lavinija, et al.
Publicado: (2021)

Factors influencing readthrough therapy for frequent cystic fibrosis premature termination codons
por: Pranke, Iwona, et al.
Publicado: (2018)

Effect of small molecule eRF3 degraders on premature termination codon readthrough
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2021)

Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner
por: Chen, Yanan, et al.
Publicado: (2020)

635 Genome-wide screen to uncover genes promoting premature termination codon readthrough
por: Wong, E., et al.
Publicado: (2022)

MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution
por: Torices, Leire, et al.
Publicado: (2021)

Aminoglycoside-stimulated readthrough of premature termination codons in selected genes involved in primary ciliary dyskinesia
por: Bukowy-Bieryllo, Zuzanna, et al.
Publicado: (2016)

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays
por: McElroy, Stuart P., et al.
Publicado: (2013)

The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418
por: Ferguson, Michael W., et al.
Publicado: (2019)

Translational readthrough potential of natural termination codons in eucaryotes – The impact of RNA sequence
por: Dabrowski, Maciej, et al.
Publicado: (2015)

Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides
por: Wangen, Jamie R, et al.
Publicado: (2020)

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
por: Frew, Jonathan, et al.
Publicado: (2020)

Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast
por: Chan, Clara S., et al.
Publicado: (2013)

Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough
por: Hosseini-Farahabadi, Sara, et al.
Publicado: (2021)

Readthrough of Premature Termination Codons in the Adenomatous Polyposis Coli Gene Restores Its Biological Activity in Human Cancer Cells
por: Floquet, Célia, et al.
Publicado: (2011)

The Effect of Gentamicin-Induced Readthrough on a Novel Premature Termination Codon of CD18 Leukocyte Adhesion Deficiency Patients
por: Simon, Amos J., et al.
Publicado: (2010)

Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2022)

Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough
por: Lee, Rhianna E., et al.
Publicado: (2022)

Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms
por: Ng, Martin Y., et al.
Publicado: (2021)

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential
por: Friesen, Westley J., et al.
Publicado: (2018)

Termination codon readthrough of NNAT mRNA regulates calcium-mediated neuronal differentiation
por: Pandit, Madhuparna, et al.
Publicado: (2023)

Evolutionary Dynamics of Abundant Stop Codon Readthrough
por: Jungreis, Irwin, et al.
Publicado: (2016)

Frontrunner in Translation: Progressive Supranuclear Palsy
por: Shoeibi, Ali, et al.
Publicado: (2019)

A Simple and Affordable Method to Create Nonsense Mutation Clones of p53 for Studying the Premature Termination Codon Readthrough Activity of PTC124
por: Chen, Chia-Chi, et al.
Publicado: (2023)

Stop Codon Context-Specific Induction of Translational Readthrough
por: Schilff, Mirco, et al.
Publicado: (2021)

Identification of stop codon readthrough genes in Saccharomyces cerevisiae
por: Namy, Olivier, et al.
Publicado: (2003)

Therapeutic suppression of premature termination codons: Mechanisms and clinical considerations (Review)
por: KARIJOLICH, JOHN, et al.
Publicado: (2014)

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae
por: Mangkalaphiban, Kotchaphorn, et al.
Publicado: (2021)

Evidence of efficient stop codon readthrough in four mammalian genes
por: Loughran, Gary, et al.
Publicado: (2014)

Premature termination codons in modern human genomes
por: Fujikura, Kohei
Publicado: (2016)

Initiation Codon Scanthrough versus Termination Codon Readthrough Demonstrates Strong Potential for Major Histocompatibility Complex Class I–restricted Cryptic Epitope Expression
por: Bullock, Timothy N.J., et al.
Publicado: (1997)

When a ribosome encounters a premature termination codon
por: Hwang, Jungwook, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_h21qe3rd3c54pfipmq09kmtsaf