Cargando…
The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and could be associated with the secretion of other i...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398282/ https://www.ncbi.nlm.nih.gov/pubmed/34443554 http://dx.doi.org/10.3390/molecules26164968 |
_version_ | 1783744801841086464 |
---|---|
author | García-Arellano, Samuel Hernández-Palma, Luis Alexis Cerpa-Cruz, Sergio Sánchez-Zuno, Gabriela Athziri Herrera-Godina, Melva Guadalupe Muñoz-Valle, José Francisco |
author_facet | García-Arellano, Samuel Hernández-Palma, Luis Alexis Cerpa-Cruz, Sergio Sánchez-Zuno, Gabriela Athziri Herrera-Godina, Melva Guadalupe Muñoz-Valle, José Francisco |
author_sort | García-Arellano, Samuel |
collection | PubMed |
description | Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and could be associated with the secretion of other immune-modulatory cytokines such as IL-25, IL-31, and IL-33. For the above, our main aim was to evaluate the IL-25, IL-31, and IL-33 secretion from recombinant human MIF (rhMIF)-stimulated peripheral blood mononuclear cells (PBMC) of RA patients. The rhMIF and lipopolysaccharide (LPS) plus rhMIF stimuli promote the secretion of IL-25, IL-31, and IL-33 (p < 0.05) from PBMC of RA patients. The study groups, the different stimuli, and the interaction between both showed a statistically significant effect on the secretion of IL-25 (p < 0.05) and IL-31 (p < 0.01). The study of the effect of the RA patient treatments and their interaction with the effect of stimuli did not show an interaction between them. In conclusion, our study generates new evidence for the role of MIF in the secretion of IL-25, IL-31, and IL-33 and its immunomodulatory effect on RA. |
format | Online Article Text |
id | pubmed-8398282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83982822021-08-29 The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis García-Arellano, Samuel Hernández-Palma, Luis Alexis Cerpa-Cruz, Sergio Sánchez-Zuno, Gabriela Athziri Herrera-Godina, Melva Guadalupe Muñoz-Valle, José Francisco Molecules Article Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and could be associated with the secretion of other immune-modulatory cytokines such as IL-25, IL-31, and IL-33. For the above, our main aim was to evaluate the IL-25, IL-31, and IL-33 secretion from recombinant human MIF (rhMIF)-stimulated peripheral blood mononuclear cells (PBMC) of RA patients. The rhMIF and lipopolysaccharide (LPS) plus rhMIF stimuli promote the secretion of IL-25, IL-31, and IL-33 (p < 0.05) from PBMC of RA patients. The study groups, the different stimuli, and the interaction between both showed a statistically significant effect on the secretion of IL-25 (p < 0.05) and IL-31 (p < 0.01). The study of the effect of the RA patient treatments and their interaction with the effect of stimuli did not show an interaction between them. In conclusion, our study generates new evidence for the role of MIF in the secretion of IL-25, IL-31, and IL-33 and its immunomodulatory effect on RA. MDPI 2021-08-17 /pmc/articles/PMC8398282/ /pubmed/34443554 http://dx.doi.org/10.3390/molecules26164968 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article García-Arellano, Samuel Hernández-Palma, Luis Alexis Cerpa-Cruz, Sergio Sánchez-Zuno, Gabriela Athziri Herrera-Godina, Melva Guadalupe Muñoz-Valle, José Francisco The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis |
title | The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis |
title_full | The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis |
title_fullStr | The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis |
title_full_unstemmed | The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis |
title_short | The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis |
title_sort | novel role of mif in the secretion of il-25, il-31, and il-33 from pbmc of patients with rheumatoid arthritis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398282/ https://www.ncbi.nlm.nih.gov/pubmed/34443554 http://dx.doi.org/10.3390/molecules26164968 |
work_keys_str_mv | AT garciaarellanosamuel thenovelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT hernandezpalmaluisalexis thenovelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT cerpacruzsergio thenovelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT sanchezzunogabrielaathziri thenovelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT herreragodinamelvaguadalupe thenovelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT munozvallejosefrancisco thenovelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT garciaarellanosamuel novelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT hernandezpalmaluisalexis novelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT cerpacruzsergio novelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT sanchezzunogabrielaathziri novelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT herreragodinamelvaguadalupe novelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis AT munozvallejosefrancisco novelroleofmifinthesecretionofil25il31andil33frompbmcofpatientswithrheumatoidarthritis |