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The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and could be associated with the secretion of other i...

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Autores principales: García-Arellano, Samuel, Hernández-Palma, Luis Alexis, Cerpa-Cruz, Sergio, Sánchez-Zuno, Gabriela Athziri, Herrera-Godina, Melva Guadalupe, Muñoz-Valle, José Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398282/
https://www.ncbi.nlm.nih.gov/pubmed/34443554
http://dx.doi.org/10.3390/molecules26164968
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author García-Arellano, Samuel
Hernández-Palma, Luis Alexis
Cerpa-Cruz, Sergio
Sánchez-Zuno, Gabriela Athziri
Herrera-Godina, Melva Guadalupe
Muñoz-Valle, José Francisco
author_facet García-Arellano, Samuel
Hernández-Palma, Luis Alexis
Cerpa-Cruz, Sergio
Sánchez-Zuno, Gabriela Athziri
Herrera-Godina, Melva Guadalupe
Muñoz-Valle, José Francisco
author_sort García-Arellano, Samuel
collection PubMed
description Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and could be associated with the secretion of other immune-modulatory cytokines such as IL-25, IL-31, and IL-33. For the above, our main aim was to evaluate the IL-25, IL-31, and IL-33 secretion from recombinant human MIF (rhMIF)-stimulated peripheral blood mononuclear cells (PBMC) of RA patients. The rhMIF and lipopolysaccharide (LPS) plus rhMIF stimuli promote the secretion of IL-25, IL-31, and IL-33 (p < 0.05) from PBMC of RA patients. The study groups, the different stimuli, and the interaction between both showed a statistically significant effect on the secretion of IL-25 (p < 0.05) and IL-31 (p < 0.01). The study of the effect of the RA patient treatments and their interaction with the effect of stimuli did not show an interaction between them. In conclusion, our study generates new evidence for the role of MIF in the secretion of IL-25, IL-31, and IL-33 and its immunomodulatory effect on RA.
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spelling pubmed-83982822021-08-29 The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis García-Arellano, Samuel Hernández-Palma, Luis Alexis Cerpa-Cruz, Sergio Sánchez-Zuno, Gabriela Athziri Herrera-Godina, Melva Guadalupe Muñoz-Valle, José Francisco Molecules Article Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and could be associated with the secretion of other immune-modulatory cytokines such as IL-25, IL-31, and IL-33. For the above, our main aim was to evaluate the IL-25, IL-31, and IL-33 secretion from recombinant human MIF (rhMIF)-stimulated peripheral blood mononuclear cells (PBMC) of RA patients. The rhMIF and lipopolysaccharide (LPS) plus rhMIF stimuli promote the secretion of IL-25, IL-31, and IL-33 (p < 0.05) from PBMC of RA patients. The study groups, the different stimuli, and the interaction between both showed a statistically significant effect on the secretion of IL-25 (p < 0.05) and IL-31 (p < 0.01). The study of the effect of the RA patient treatments and their interaction with the effect of stimuli did not show an interaction between them. In conclusion, our study generates new evidence for the role of MIF in the secretion of IL-25, IL-31, and IL-33 and its immunomodulatory effect on RA. MDPI 2021-08-17 /pmc/articles/PMC8398282/ /pubmed/34443554 http://dx.doi.org/10.3390/molecules26164968 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
García-Arellano, Samuel
Hernández-Palma, Luis Alexis
Cerpa-Cruz, Sergio
Sánchez-Zuno, Gabriela Athziri
Herrera-Godina, Melva Guadalupe
Muñoz-Valle, José Francisco
The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis
title The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis
title_full The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis
title_fullStr The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis
title_full_unstemmed The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis
title_short The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis
title_sort novel role of mif in the secretion of il-25, il-31, and il-33 from pbmc of patients with rheumatoid arthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398282/
https://www.ncbi.nlm.nih.gov/pubmed/34443554
http://dx.doi.org/10.3390/molecules26164968
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