Cargando…

Effective Osteogenic Priming of Mesenchymal Stem Cells through LNA-ASOs-Mediated Sfrp1 Gene Silencing

Mesenchymal stem cell (MSC) transplantation has emerged as a promising approach for bone regeneration. Importantly, the beneficial effects of MSCs can be improved by modulating the expression levels of specific genes to stimulate MSC osteogenic differentiation. We have previously shown that Smurf1 s...

Descripción completa

Detalles Bibliográficos
Autores principales:	García-Sánchez, Daniel, González-González, Alberto, García-García, Patricia, Reyes, Ricardo, Pérez-Núñez, María Isabel, Riancho, José A., Évora, Carmen, Rodríguez-Rey, José Carlos, Pérez-Campo, Flor M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398380/ https://www.ncbi.nlm.nih.gov/pubmed/34452242 http://dx.doi.org/10.3390/pharmaceutics13081277

Ejemplares similares

Smurf1 Silencing Using a LNA‐ASOs/Lipid Nanoparticle System to Promote Bone Regeneration
por: García‐García, Patricia, et al.
Publicado: (2019)

Nanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice
por: García-García, Patricia, et al.
Publicado: (2022)

Engineering a Pro-Osteogenic Secretome through the Transient Silencing of the Gene Encoding Secreted Frizzled Related Protein 1
por: García-Sánchez, Daniel, et al.
Publicado: (2023)

Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells
por: García-Sánchez, Daniel, et al.
Publicado: (2019)

Epigenetic Mechanisms Regulating Mesenchymal Stem Cell Differentiation
por: Pérez-Campo, Flor M., et al.
Publicado: (2015)

Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
por: González-González, Alberto, et al.
Publicado: (2020)

Communication between bone marrow mesenchymal stem cells and multiple myeloma cells: Impact on disease progression
por: García-Sánchez, Daniel, et al.
Publicado: (2023)

The Silencing of SFRP2 Expression in ESCC Is Due to Methylation of the Gene Promoter
por: Liu, Qian, et al.
Publicado: (2019)

Miniature Wide-Band Noise-Canceling CMOS LNA †
por: Galante-Sempere, David, et al.
Publicado: (2022)

SFRP1 induces a stem cell phenotype in prostate cancer cells
por: Losada-García, Alberto, et al.
Publicado: (2023)

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury
por: Moreno, Pedro M.D., et al.
Publicado: (2018)

Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity
por: Amodio, Nicola, et al.
Publicado: (2018)

Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells
por: Toraño, Estela G., et al.
Publicado: (2016)

Influence of inflammatory conditions provided by macrophages on osteogenic ability of mesenchymal stem cells
por: Vallés, Gema, et al.
Publicado: (2020)

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts
por: Shin, Minwook, et al.
Publicado: (2022)

Targeting LDL Cholesterol With LNA
por: Krieg, Arthur M
Publicado: (2012)

SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo
por: Cruz-Hernández, Carlos D., et al.
Publicado: (2020)

SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway
por: Jin, Luyuan, et al.
Publicado: (2017)

Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels
por: Bernascone, Ilenia, et al.
Publicado: (2019)

Epigenetic gene silencing by heterochromatin primes fungal resistance
por: Torres-Garcia, Sito, et al.
Publicado: (2020)

Stimulation of ribosomal frameshifting by antisense LNA
por: Yu, Chien-Hung, et al.
Publicado: (2010)

Electronic Structures of LNA Phosphorothioate Oligonucleotides
por: Bohr, Henrik G., et al.
Publicado: (2017)

LNA blockers for improved amplification selectivity
por: Prout, Jaime, et al.
Publicado: (2023)

The role of Sfrp and DKK proteins in cardiomyocyte development
por: Hsueh, Ying‐Chang, et al.
Publicado: (2021)

TRPM8 Channel Promotes the Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells
por: Henao, Juan C., et al.
Publicado: (2021)

A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
por: Gupta, Nidhi, et al.
Publicado: (2010)

Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1
por: Hu, Xumin, et al.
Publicado: (2019)

Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP
por: Xie, Yang, et al.
Publicado: (2021)

PPARγ silencing enhances osteogenic differentiation of human adipose-derived mesenchymal stem cells
por: Lee, Mon-Juan, et al.
Publicado: (2013)

Design of LNA probes that improve mismatch discrimination
por: You, Yong, et al.
Publicado: (2006)

Amplification and Re-Generation of LNA-Modified Libraries
por: Doessing, Holger, et al.
Publicado: (2012)

Effects of Systemic or Local Administration of Mesenchymal Stem Cells from Patients with Osteoporosis or Osteoarthritis on Femoral Fracture Healing in a Mouse Model
por: Laguna, Esther, et al.
Publicado: (2022)

SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma
por: Guo, Min, et al.
Publicado: (2021)

Fak silencing impairs osteogenic differentiation of bone mesenchymal stem cells induced by uniaxial mechanical stretch
por: Hu, Pei, et al.
Publicado: (2019)

Retraction Notice to: Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1
por: Hu, Xumin, et al.
Publicado: (2022)

Study of SFRP1 and SFRP2 methylation status in patients with de novo Acute Myeloblastic Leukemia
por: Ghasemi, Ali, et al.
Publicado: (2015)

DNA methylation of SFRP1, SFRP2, and WIF1 and prognosis of postoperative colorectal cancer patients
por: Liu, Xinyan, et al.
Publicado: (2019)

Specific RNP capture with antisense LNA/DNA mixmers
por: Rogell, Birgit, et al.
Publicado: (2017)

Refining LNA safety profile by controlling phosphorothioate stereochemistry
por: Funder, Erik Daa, et al.
Publicado: (2020)

An Inductorless Gain-Controllable Wideband LNA Based on CCCIIs
por: Wan, Qiuzhen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gvg1apnlml8k649i0koi4qvhd9