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Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists

TrkB is a tyrosine kinase receptor that is activated upon binding to brain-derived neurotrophic factor (BDNF). To date, the search for low-molecular-weight molecules mimicking BDNF’s action has been unsuccessful. Several molecules exerting antidepressive effects in vivo, such as 7,8-DHF, have been s...

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Detalles Bibliográficos
Autores principales: Pankiewicz, Piotr, Szybiński, Marcin, Kisielewska, Katarzyna, Gołębiowski, Filip, Krzemiński, Patryk, Rutkowska-Włodarczyk, Izabela, Moszczyński-Pętkowski, Rafał, Gurba-Bryśkiewicz, Lidia, Delis, Monika, Mulewski, Krzysztof, Smuga, Damian, Dominowski, Jakub, Janusz, Artur, Górka, Michał, Abramski, Krzysztof, Napiórkowska, Agnieszka, Nowotny, Marcin, Dubiel, Krzysztof, Kalita, Katarzyna, Wieczorek, Maciej, Pieczykolan, Jerzy, Matłoka, Mikołaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398766/
https://www.ncbi.nlm.nih.gov/pubmed/34451801
http://dx.doi.org/10.3390/ph14080704