Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents

Acid reducing agents (ARAs) reduce the dissolution rate of weakly basic drugs in the stomach potentially leading to lower bioavailability. Formulating the API as a rapidly dissolving salt is one strategy employed to reduce the impact of ARAs on dissolution of such drugs. In the present work, a model...

Descripción completa

Detalles Bibliográficos
Autores principales: Chirumamilla, Siri Kalyan, Banala, Venkatesh Teja, Jamei, Masoud, Turner, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398830/
https://www.ncbi.nlm.nih.gov/pubmed/34452130
http://dx.doi.org/10.3390/pharmaceutics13081169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398830/
https://www.ncbi.nlm.nih.gov/pubmed/34452130
http://dx.doi.org/10.3390/pharmaceutics13081169

Ejemplares similares