Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1)

FAH domain containing protein 1 (FAHD1) acts as oxaloacetate decarboxylase in mitochondria, contributing to the regulation of the tricarboxylic acid cycle. Guided by a high-resolution X-ray structure of FAHD1 liganded by oxalate, the enzymatic mechanism of substrate processing is analyzed in detail....

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Detalles Bibliográficos
Autores principales: Weiss, Alexander K. H., Wurzer, Richard, Klapec, Patrycia, Eder, Manuel Philip, Loeffler, Johannes R., von Grafenstein, Susanne, Monteleone, Stefania, Liedl, Klaus R., Jansen-Dürr, Pidder, Gstach, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398924/
https://www.ncbi.nlm.nih.gov/pubmed/34443596
http://dx.doi.org/10.3390/molecules26165009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8398924/
https://www.ncbi.nlm.nih.gov/pubmed/34443596
http://dx.doi.org/10.3390/molecules26165009

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