Inhibition of Cysteine Proteases by 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea

The specificity of inhibition by 6,6′-dihydroxythiobinupharidine (DTBN) on cysteine proteases was demonstrated in this work. There were differences in the extent of inhibition, reflecting active site structural-steric and biochemical differences. Cathepsin S (IC(50) = 3.2 μM) was most sensitive to i...

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Detalles Bibliográficos
Autores principales: Waidha, Kamran, Zurgil, Udi, Ben-Zeev, Efrat, Gopas, Jacob, Rajendran, Saravanakumar, Golan-Goldhirsh, Avi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399019/
https://www.ncbi.nlm.nih.gov/pubmed/34443335
http://dx.doi.org/10.3390/molecules26164743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399019/
https://www.ncbi.nlm.nih.gov/pubmed/34443335
http://dx.doi.org/10.3390/molecules26164743

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