Characterization of ACE Inhibitors and AT(1)R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model

Blood-pressure-lowering drugs are proposed to foster SARS-CoV-2 infection by pharmacological upregulation of angiotensin-converting enzyme 2 (ACE2), the binding partner of the virus spike (S) protein, located on the surface of the host cells. Conversely, it is postulated that angiotensin–renin syste...

Descripción completa

Detalles Bibliográficos
Autores principales: Reus, Philipp, Schneider, Ann-Kathrin, Ulshöfer, Thomas, Henke, Marina, Bojkova, Denisa, Cinatl, Jindrich, Ciesek, Sandra, Geisslinger, Gerd, Laux, Volker, Grättinger, Mira, Gribbon, Philip, Schiffmann, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399150/
https://www.ncbi.nlm.nih.gov/pubmed/34440554
http://dx.doi.org/10.3390/life11080810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399150/
https://www.ncbi.nlm.nih.gov/pubmed/34440554
http://dx.doi.org/10.3390/life11080810

Ejemplares similares