Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration

About 40 years ago the lipidization of hydrophilic drugs was proposed to induce their brain targeting by transforming them into lipophilic prodrugs. Unfortunately, lipidization often transforms a hydrophilic neuroactive agent into an active efflux transporter (AET) substrate, with consequent rejecti...

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Detalles Bibliográficos
Autores principales: Botti, Giada, Dalpiaz, Alessandro, Pavan, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399330/
https://www.ncbi.nlm.nih.gov/pubmed/34452105
http://dx.doi.org/10.3390/pharmaceutics13081144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399330/
https://www.ncbi.nlm.nih.gov/pubmed/34452105
http://dx.doi.org/10.3390/pharmaceutics13081144

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