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Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration
About 40 years ago the lipidization of hydrophilic drugs was proposed to induce their brain targeting by transforming them into lipophilic prodrugs. Unfortunately, lipidization often transforms a hydrophilic neuroactive agent into an active efflux transporter (AET) substrate, with consequent rejecti...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399330/ https://www.ncbi.nlm.nih.gov/pubmed/34452105 http://dx.doi.org/10.3390/pharmaceutics13081144 |