A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes

Environmental factors including viruses, diet, and the metabolome have been linked with the appearance of islet autoimmunity (IA) that precedes development of type 1 diabetes (T1D). We measured global DNA methylation (DNAm) and untargeted metabolomics prior to IA and at the time of seroconversion to...

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Detalles Bibliográficos
Autores principales: Vigers, Tim, Vanderlinden, Lauren A., Johnson, Randi K., Carry, Patrick M., Yang, Ivana, DeFelice, Brian C., Kaizer, Alexander M., Pyle, Laura, Rewers, Marian, Fiehn, Oliver, Norris, Jill M., Kechris, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399445/
https://www.ncbi.nlm.nih.gov/pubmed/34436483
http://dx.doi.org/10.3390/metabo11080542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399445/
https://www.ncbi.nlm.nih.gov/pubmed/34436483
http://dx.doi.org/10.3390/metabo11080542

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