Fluorescence Cross-Correlation Spectroscopy Yields True Affinity and Binding Kinetics of Plasmodium Lactate Transport Inhibitors

Blocking lactate export in the parasitic protozoan Plasmodium falciparum is a novel strategy to combat malaria. We discovered small drug-like molecules that inhibit the sole plasmodial lactate transporter, PfFNT, and kill parasites in culture. The pentafluoro-3-hydroxy-pent-2-en-1-one BH296 blocks P...

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Detalles Bibliográficos
Autores principales: Jakobowska, Iga, Becker, Frank, Minguzzi, Stefano, Hansen, Kerrin, Henke, Björn, Epalle, Nathan Hugo, Beitz, Eric, Hannus, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399565/
https://www.ncbi.nlm.nih.gov/pubmed/34451854
http://dx.doi.org/10.3390/ph14080757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399565/
https://www.ncbi.nlm.nih.gov/pubmed/34451854
http://dx.doi.org/10.3390/ph14080757

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