Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice

P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are co-localized at the blood–brain barrier, where they display functional redundancy to restrict the brain distribution of dual P-gp/BCRP substrate drugs. We used positron emission tomography (PET) with the metabolically stable P-gp/...

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Detalles Bibliográficos
Autores principales: Hernández-Lozano, Irene, Mairinger, Severin, Traxl, Alexander, Sauberer, Michael, Filip, Thomas, Stanek, Johann, Kuntner, Claudia, Wanek, Thomas, Langer, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399697/
https://www.ncbi.nlm.nih.gov/pubmed/34452247
http://dx.doi.org/10.3390/pharmaceutics13081286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399697/
https://www.ncbi.nlm.nih.gov/pubmed/34452247
http://dx.doi.org/10.3390/pharmaceutics13081286

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