Impact of a non-constant baseline hazard on detection of time-dependent treatment effects: a simulation study

BACKGROUND: Non-proportional hazards are common with time-to-event data but the majority of randomised clinical trials (RCTs) are designed and analysed using approaches which assume the treatment effect follows proportional hazards (PH). Recent advances in oncology treatments have identified two for...

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Detalles Bibliográficos
Autores principales: Jachno, Kim, Heritier, Stephane, Wolfe, Rory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399795/
https://www.ncbi.nlm.nih.gov/pubmed/34454428
http://dx.doi.org/10.1186/s12874-021-01372-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399795/
https://www.ncbi.nlm.nih.gov/pubmed/34454428
http://dx.doi.org/10.1186/s12874-021-01372-0

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