Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B)

This work describes, for the first time, the synthesis of dialkyl (2-arylquinolin-8-yl)phosphonate derivatives. The preparation was carried out through a direct and simple process as a multicomponent Povarov reaction of aminophenylphosphonates, aldehydes, and styrenes and subsequent oxidation with 2...

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Detalles Bibliográficos
Autores principales: Selas, Asier, Fuertes, María, Melcón-Fernández, Estela, Pérez-Pertejo, Yolanda, Reguera, Rosa M., Balaña-Fouce, Rafael, Knudsen, Birgitta R., Palacios, Francisco, Alonso, Concepcion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399847/
https://www.ncbi.nlm.nih.gov/pubmed/34451880
http://dx.doi.org/10.3390/ph14080784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399847/
https://www.ncbi.nlm.nih.gov/pubmed/34451880
http://dx.doi.org/10.3390/ph14080784

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