Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

Patients with chronic kidney disease (CKD) suffer from arterial media calcification and a disturbed bone metabolism. Tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes the calcification inhibitor pyrophosphate (PPi) into inorganic phosphate (Pi) and thereby stimulates arterial media calcifica...

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Detalles Bibliográficos
Autores principales: Opdebeeck, Britt, Neven, Ellen, Millán, José Luis, Pinkerton, Anthony B., D’Haese, Patrick C., Verhulst, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399849/
https://www.ncbi.nlm.nih.gov/pubmed/34452102
http://dx.doi.org/10.3390/pharmaceutics13081138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399849/
https://www.ncbi.nlm.nih.gov/pubmed/34452102
http://dx.doi.org/10.3390/pharmaceutics13081138

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