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Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

Patients with chronic kidney disease (CKD) suffer from arterial media calcification and a disturbed bone metabolism. Tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes the calcification inhibitor pyrophosphate (PPi) into inorganic phosphate (Pi) and thereby stimulates arterial media calcifica...

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Detalles Bibliográficos
Autores principales:	Opdebeeck, Britt, Neven, Ellen, Millán, José Luis, Pinkerton, Anthony B., D’Haese, Patrick C., Verhulst, Anja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399849/ https://www.ncbi.nlm.nih.gov/pubmed/34452102 http://dx.doi.org/10.3390/pharmaceutics13081138

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