A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents

An efficient synthetic methodology for the preparation of 3-amino 1,5-dihydro-2H-pyrrol-2-ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is reported. In addition, the densely substituted lactam substrates show in vitro cytotoxicity, inhibiting the growth of car...

Descripción completa

Detalles Bibliográficos
Autores principales: del Corte, Xabier, López-Francés, Adrián, Maestro, Aitor, Villate-Beitia, Ilia, Sainz-Ramos, Myriam, Martínez de Marigorta, Edorta, Pedraz, José Luis, Palacios, Francisco, Vicario, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400033/
https://www.ncbi.nlm.nih.gov/pubmed/34451879
http://dx.doi.org/10.3390/ph14080782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400033/
https://www.ncbi.nlm.nih.gov/pubmed/34451879
http://dx.doi.org/10.3390/ph14080782

Ejemplares similares