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New Insights into Beta-Lactam Resistance of Streptococcus pneumoniae: Serine Protease HtrA Degrades Altered Penicillin-Binding Protein 2x

Reduced amounts of the essential penicillin-binding protein 2x (PBP2x) were detected in two cefotaxime-resistant Streptococcus pneumoniae laboratory mutants C405 and C606. These mutants contain two or four mutations in the penicillin-binding domain of PBP2x, respectively. The transcription of the pb...

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Detalles Bibliográficos
Autores principales:	Peters, Katharina, Schweizer, Inga, Hakenbeck, Regine, Denapaite, Dalia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400419/ https://www.ncbi.nlm.nih.gov/pubmed/34442764 http://dx.doi.org/10.3390/microorganisms9081685

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