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Chemoinformatics Analyses of Tau Ligands Reveal Key Molecular Requirements for the Identification of Potential Drug Candidates against Tauopathies

Tau is a highly soluble protein mainly localized at a cytoplasmic level in the neuronal cells, which plays a crucial role in the regulation of microtubule dynamic stability. Recent studies have demonstrated that several factors, such as hyperphosphorylation or alterations of Tau metabolism, may cont...

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Detalles Bibliográficos
Autores principales: Pinzi, Luca, Tinivella, Annachiara, Rastelli, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400687/
https://www.ncbi.nlm.nih.gov/pubmed/34443629
http://dx.doi.org/10.3390/molecules26165039