Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors

A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA IX and XII activity. Six compounds were found to be potent and selective CA IX inhibitors with the order of 5g > 5b > 5d > 5e > 5g > 5...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., Youssif, Bahaa G. M., Taher, Ehab S., Abdelazeem, Ahmed H., Abdelhamid, Antar A., Marzouk, Adel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400968/
https://www.ncbi.nlm.nih.gov/pubmed/34443307
http://dx.doi.org/10.3390/molecules26164718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400968/
https://www.ncbi.nlm.nih.gov/pubmed/34443307
http://dx.doi.org/10.3390/molecules26164718

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